Genome-Wide Expression Profiling and Phenotypic Analysis of Downstream Targets Identify the Fox Transcription Factor Jumeau as a Master Regulator of Cardiac Progenitor Cell Division
M Rezaul Hasan, Andrew J Kump, Evelyn C Stepaniak, Manoj Panta, Kuncha Shashidhar, Rajnandani Katariya, Mofazzal K Sabbir, Kristopher R Schwab, Mark H Inlow, Ye Chen, Shaad M Ahmad, Justyna Fert-Bober · 2024
Read Genome-Wide Expression Profiling and Phenotypic Analysis of Downstream Targets Identify the Fox Transcription Factor Jumeau as a Master Regulator of Cardiac Progenitor Cell Division by M Rezaul Hasan, Andrew J Kump, Evelyn C Stepaniak, Manoj Panta, Kuncha Shashidhar, Rajnandani Katariya, Mofazzal K Sabbir, Kristopher R Schwab, Mark H Inlow, Ye Chen, Shaad M Ahmad, Justyna Fert-Bober (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11641245.txt.
Description
Rezaul Hasan and co-authors study a gene called jumeau in fruit flies in this 2024 paper. The gene belongs to a family that helps guide heart growth in flies and mammals. Earlier work showed this gene helps heart starter cells form and divide. The team set out to find which other genes it controls.
They compared gene activity in cells from normal embryos and from embryos lacking the gene. Genes tied to cell division stood out among its targets. Tests then found 21 target genes that help heart starter cells divide. One gene, Rx, was studied in depth. Many targets also interact with each other, which points to the gene as a hub.
Catalog record
| CREATOR | M Rezaul Hasan, Andrew J Kump, Evelyn C Stepaniak, Manoj Panta, Kuncha Shashidhar, Rajnandani Katariya, Mofazzal K Sabbir, Kristopher R Schwab, Mark H Inlow, Ye Chen, Shaad M Ahmad, Justyna Fert-Bober |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |