Molecular Composition and Kinetics of B Cells During Ibrutinib Treatment in Patients with Chronic Lymphocytic Leukemia
Sólja Remisdóttir Veyhe, Oriane Cédile, Sara Kamuk Dahlmann, Jakub Krejcik, Niels Abildgaard, Thor Høyer, Michael Boe Møller, Mads Thomassen, Karen Juul-Jensen, Henrik Frederiksen, Karen Dybkær, Marcus Høy Hansen, Charlotte Guldborg Nyvold, Behzad Imanian · 2024
Read Molecular Composition and Kinetics of B Cells During Ibrutinib Treatment in Patients with Chronic Lymphocytic Leukemia by Sólja Remisdóttir Veyhe, Oriane Cédile, Sara Kamuk Dahlmann, Jakub Krejcik, Niels Abildgaard, Thor Høyer, Michael Boe Møller, Mads Thomassen, Karen Juul-Jensen, Henrik Frederiksen, Karen Dybkær, Marcus Høy Hansen, Charlotte Guldborg Nyvold, Behzad Imanian (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11641073.txt.
Description
Sólja Remisdóttir Veyhe and co-authors track how a leukemia drug reshapes patients' B cells over years, in this 2024 study. The drug ibrutinib blocks a signal that chronic lymphocytic leukemia cells depend on. Following twenty-four patients with deep genetic and single-cell tools, the team watched the cancer clone under treatment.
In ibrutinib patients who first responded, the clone stayed large and steady for up to three years, with little genetic drift. A rival drug, by contrast, shrank its clone toward vanishing. The authors read ibrutinib as freezing the cancer's landscape rather than clearing it.
Catalog record
| CREATOR | Sólja Remisdóttir Veyhe, Oriane Cédile, Sara Kamuk Dahlmann, Jakub Krejcik, Niels Abildgaard, Thor Høyer, Michael Boe Møller, Mads Thomassen, Karen Juul-Jensen, Henrik Frederiksen, Karen Dybkær, Marcus Høy Hansen, Charlotte Guldborg Nyvold, Behzad Imanian |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |