Is Fluoride Blameless?—The Influence of Fluorine Compounds on the Invasiveness of the Human Glioma-like Cell Line U-87
Wojciech Żwierełło, Agnieszka Maruszewska, Marta Skórka-Majewicz, Agata Wszołek, Izabela Gutowska · 2024
Read Is Fluoride Blameless?—The Influence of Fluorine Compounds on the Invasiveness of the Human Glioma-like Cell Line U-87 by Wojciech Żwierełło, Agnieszka Maruszewska, Marta Skórka-Majewicz, Agata Wszołek, Izabela Gutowska (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11641017.txt.
Description
Wojciech Żwierełło and co-authors ask whether fluoride, best known for protecting teeth, can make brain tumour cells more invasive, in a 2024 paper. Glioblastoma is among the most stubborn cancers, and fluoride's harm to the developing nervous system is documented. No one had tested fluoride against tumour spread directly. The team exposed a human glioblastoma cell line, U-87, to sodium fluoride at doses matching high body levels.
They measured how the cells migrated and invaded, and how much of two tissue-chewing enzymes they released. Signals in two growth pathways tied to invasiveness were also tracked. At the tested doses, the fluoride pushed the cells toward a more invasive character, the authors report. The study is a first step, done in dishes rather than patients, but it raises a question worth following for a chemical found in water and toothpaste.
Catalog record
| CREATOR | Wojciech Żwierełło, Agnieszka Maruszewska, Marta Skórka-Majewicz, Agata Wszołek, Izabela Gutowska |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |