Smart control lipid-based nanocarriers for fine-tuning gut hormone secretion
Yining Xu, Cécilia Bohns Michalowski, Jackie Koehler, Tamana Darwish, Nunzio Guccio, Constanza Alcaino, Inês Domingues, Wunan Zhang, Valentina Marotti, Matthias Van Hul, Paola Paone, Melitini Koutsoviti, Ben J. Boyd, Daniel J. Drucker, Patrice D. Cani, Frank Reimann, Fiona M. Gribble, Ana Beloqui · 2024
Read Smart control lipid-based nanocarriers for fine-tuning gut hormone secretion by Yining Xu, Cécilia Bohns Michalowski, Jackie Koehler, Tamana Darwish, Nunzio Guccio, Constanza Alcaino, Inês Domingues, Wunan Zhang, Valentina Marotti, Matthias Van Hul, Paola Paone, Melitini Koutsoviti, Ben J. Boyd, Daniel J. Drucker, Patrice D. Cani, Frank Reimann, Fiona M. Gribble, Ana Beloqui (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11641013.txt.
Description
Yining Xu and co-authors present a 2024 study on tiny fat-based carriers that nudge gut hormone release. Cells in the gut wall sense food and release hormones such as GLP-1, GIP, and PYY, which help control blood sugar and hunger. The team asked whether common fat ingredients used in drug products can switch those cells on. They tested this in mouse and human gut organoids, small lab-grown gut models.
The fat ingredients did switch on food-sensing switches on the gut cells. Packed into carriers, they raised hormone release from the cells that make these hormones. In mice, changing the fat mix, dose, or size of the carriers changed the strength of the effect. Mice with high blood sugar also responded. The study frames the carriers as a cheap, needle-free way to tune hormones, though all tests so far are in labs and mice.
Catalog record
| CREATOR | Yining Xu, Cécilia Bohns Michalowski, Jackie Koehler, Tamana Darwish, Nunzio Guccio, Constanza Alcaino, Inês Domingues, Wunan Zhang, Valentina Marotti, Matthias Van Hul, Paola Paone, Melitini Koutsoviti, Ben J. Boyd, Daniel J. Drucker, Patrice D. Cani, Frank Reimann, Fiona M. Gribble, Ana Beloqui |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |