Melatonin Attenuates Ferritinophagy/Ferroptosis by Acting on Autophagy in the Liver of an Autistic Mouse Model BTBR T+Itpr3tf/J
Giorgia Cominelli, Claudio Lonati, Daniela Pinto, Fabio Rinaldi, Caterina Franco, Gaia Favero, Rita Rezzani · 2024
Read Melatonin Attenuates Ferritinophagy/Ferroptosis by Acting on Autophagy in the Liver of an Autistic Mouse Model BTBR T+Itpr3tf/J by Giorgia Cominelli, Claudio Lonati, Daniela Pinto, Fabio Rinaldi, Caterina Franco, Gaia Favero, Rita Rezzani (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11640888.txt.
Description
Giorgia Cominelli and co-authors test melatonin in the liver of a mouse model of autism, in work from 2024. Melatonin is best known for sleep, but it also affects cell cleanup systems. The team asked whether it could ease harmful iron build-up in liver cells.
They compared treated and untreated mice using tissue stains, antibody tests, and protein blots. Key markers tracked cell cleanup and a form of cell death linked to iron. Livers from the model strain showed clear changes in shape and in those markers. Melatonin shifted several markers back toward normal. The work is early and in mice, but it maps a path for further study.
Catalog record
| CREATOR | Giorgia Cominelli, Claudio Lonati, Daniela Pinto, Fabio Rinaldi, Caterina Franco, Gaia Favero, Rita Rezzani |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |