Preferred Orientation of Hydroxyapatite Ceramics Along the c-Axis Promotes Osteoblast Differentiation
Kitaru Suzuki, Masaki Tamazawa, Erika Onuma, Michiyo Honda, Mamoru Aizawa · 2024
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Description
Kitaru Suzuki and co-authors test whether crystal orientation in a bone like ceramic changes bone cell growth, in a 2024 paper. The ceramic, hydroxyapatite, matches the main mineral in bone and tooth enamel and is used in artificial bone. The team made ceramics with a preferred crystal face exposed by a templated growth method.
Bone forming cells grown on the oriented ceramic showed higher early bone marker activity than cells on standard ceramic. Protein patterns also differed between the two surfaces. The results suggest the exposed crystal face aids early bone differentiation. Tuning crystal structure could thus yield stronger artificial bone materials.
Catalog record
| CREATOR | Kitaru Suzuki, Masaki Tamazawa, Erika Onuma, Michiyo Honda, Mamoru Aizawa |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |