Oxidative DNA Damage and Arterial Hypertension in Light of Current ESC Guidelines
Radka Hazuková, Zdeněk Zadák, Miloslav Pleskot, Petr Zdráhal, Martin Pumprla, Miloš Táborský · 2024
Read Oxidative DNA Damage and Arterial Hypertension in Light of Current ESC Guidelines by Radka Hazuková, Zdeněk Zadák, Miloslav Pleskot, Petr Zdráhal, Martin Pumprla, Miloš Táborský (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11640817.txt.
Description
Radka Hazuková and co-authors argue in this 2024 review that DNA damage from oxidative stress sits at the root of high blood pressure. High blood pressure is a top driver of heart disease worldwide, and stress chemistry has long been blamed. The authors say the key step is harm to DNA itself, through changed building blocks and breaks in the strand.
That harm, they propose, starts a chain of swelling, scarring, and vessel stiffening that ends in lasting pressure rises. They fold the idea into the standard account of the disease and set it beside current European care guidance. The payoff they see is new drug targets in the cell's DNA repair paths.
Catalog record
| CREATOR | Radka Hazuková, Zdeněk Zadák, Miloslav Pleskot, Petr Zdráhal, Martin Pumprla, Miloš Táborský |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |