Distribution of the p66Shc Adaptor Protein Among Mitochondrial and Mitochondria—Associated Membranes Fractions in Normal and Oxidative Stress Conditions
Magdalena Lebiedzinska-Arciszewska, Barbara Pakula, Massimo Bonora, Sonia Missiroli, Yaiza Potes, Patrycja Jakubek-Olszewska, Ines C M Simoes, Paolo Pinton, Mariusz R Wieckowski, Wieslawa Jarmuszkiewicz · 2024
Read Distribution of the p66Shc Adaptor Protein Among Mitochondrial and Mitochondria—Associated Membranes Fractions in Normal and Oxidative Stress Conditions by Magdalena Lebiedzinska-Arciszewska, Barbara Pakula, Massimo Bonora, Sonia Missiroli, Yaiza Potes, Patrycja Jakubek-Olszewska, Ines C M Simoes, Paolo Pinton, Mariusz R Wieckowski, Wieslawa Jarmuszkiewicz (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11640770.txt.
Description
Magdalena Lebiedzinska-Arciszewska and co-authors present a 2024 study on where a cell protein called p66Shc sits inside cells. The protein helps control growth signals, energy use, and the making of reactive oxygen. Under stress it can move into the mitochondria, the cell's power plants, and help produce harmful peroxide there.
The team mapped the protein across cell compartments in mouse liver and in a human liver cell line. They used careful methods to purify the narrow contact zones where two cell structures, the endoplasmic reticulum and mitochondria, touch. Their results add fresh proof that a pool of the protein sits in those contact zones. That spot could let it shape choices between cell survival and cell death.
Catalog record
| CREATOR | Magdalena Lebiedzinska-Arciszewska, Barbara Pakula, Massimo Bonora, Sonia Missiroli, Yaiza Potes, Patrycja Jakubek-Olszewska, Ines C M Simoes, Paolo Pinton, Mariusz R Wieckowski, Wieslawa Jarmuszkiewicz |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |