Impairment of Intermediate Filament Expression Reveals Impact on Cell Functions Independent from Keratinocyte Transformation
Charlotte Klein, Imke Ramminger, Shuoqiu Bai, Thorsten Steinberg, Pascal Tomakidi, Ralf Weiskirchen · 2024
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Description
Charlotte Klein and co-authors test what happens when skin cells lose parts of their inner scaffold, in a 2024 study. The scaffold, built from filament proteins, holds cell shape and supports daily tissue balance. Its flaws are poorly grasped at the cell level. The team quieted three scaffold genes in mouth skin cells at unlike stages of change, some pre-treated with alcohol.
Loss of any of the three slowed growth shifts and altered the packing of genetic material. A nuclear guard protein and a skin maturity marker also fell. Quieting that marker in turn cut scaffold levels, hinting at a two-way link. The authors say targeted scaffold loss is a sharp tool for probing tissue health.
Catalog record
| CREATOR | Charlotte Klein, Imke Ramminger, Shuoqiu Bai, Thorsten Steinberg, Pascal Tomakidi, Ralf Weiskirchen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |