The Challenge of External Generalisability: Insights from the Bicentric Validation of a [68Ga]Ga-PSMA-11 PET Based Radiomics Signature for Primary Prostate Cancer Characterisation Using Histopathology as Reference
Samuele Ghezzo, Praveen Gurunath Bharathi, Heying Duan, Paola Mapelli, Philipp Sorgo, Guido Alejandro Davidzon, Carolina Bezzi, Benjamin Inbeh Chung, Ana Maria Samanes Gajate, Alan Eih Chih Thong, Tommaso Russo, Giorgio Brembilla, Andreas Markus Loening, Pejman Ghanouni, Anna Grattagliano, Alberto B · 2024
Read The Challenge of External Generalisability: Insights from the Bicentric Validation of a [68Ga]Ga-PSMA-11 PET Based Radiomics Signature for Primary Prostate Cancer Characterisation Using Histopathology as Reference by Samuele Ghezzo, Praveen Gurunath Bharathi, Heying Duan, Paola Mapelli, Philipp Sorgo, Guido Alejandro Davidzon, Carolina Bezzi, Benjamin Inbeh Chung, Ana Maria Samanes Gajate, Alan Eih Chih Thong, Tommaso Russo, Giorgio Brembilla, Andreas Markus Loening, Pejman Ghanouni, Anna Grattagliano, Alberto B (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11640655.txt.
Description
Ghezzo and co-authors test whether a PET-based radiomics signature for prostate cancer works beyond its home center. The signature reads patterns in PSMA-11 PET scans to characterize primary prostate tumors. Tissue pathology served as the reference truth. A two-center validation checked external generalisability, the weak point of many scan-based models, where accuracy often drops on data from new hospitals and scanners.
Catalog record
| CREATOR | Samuele Ghezzo, Praveen Gurunath Bharathi, Heying Duan, Paola Mapelli, Philipp Sorgo, Guido Alejandro Davidzon, Carolina Bezzi, Benjamin Inbeh Chung, Ana Maria Samanes Gajate, Alan Eih Chih Thong, Tommaso Russo, Giorgio Brembilla, Andreas Markus Loening, Pejman Ghanouni, Anna Grattagliano, Alberto B |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |