Extract of Curculigo capitulata Ameliorates Postmenopausal Osteoporosis by Promoting Osteoblast Proliferation and Differentiation
Ying Wang, Xueru Wang, Kaijin Wang, Weiwei Qin, Ning Li · 2024
Read Extract of Curculigo capitulata Ameliorates Postmenopausal Osteoporosis by Promoting Osteoblast Proliferation and Differentiation by Ying Wang, Xueru Wang, Kaijin Wang, Weiwei Qin, Ning Li (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11640542.txt.
Description
Ying Wang and four co-authors present a 2024 study on a plant extract that may fight bone loss after menopause. When estrogen falls, bones thin and fracture risk climbs, and current drugs carry side effects. The plant Curculigo capitulata is used in tradition to strengthen bones. The team tested its extract on bone-forming cells in dishes and on mice whose ovaries were removed to mimic menopause.
The extract made bone-forming cells grow and mature faster, with more mineral deposits and higher bone marker levels. It switched on the estrogen receptor and a linked growth pathway, which also cut cell death. In the mice, bone integrity improved in line with the dish results. The authors present the extract as a promising candidate for treating postmenopausal bone loss. They frame the pathway findings as a mechanism worth further drug study.
Catalog record
| CREATOR | Ying Wang, Xueru Wang, Kaijin Wang, Weiwei Qin, Ning Li |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |