The Molecular Mechanism of Farnesoid X Receptor Alleviating Glucose Intolerance in Turbot (Scophthalmus maximus)
Gaochan Qin, Mingzhu Pan, Dong Huang, Xinxin Li, Yue Liu, Xiaojun Yu, Kangsen Mai, Wenbing Zhang · 2024
Read The Molecular Mechanism of Farnesoid X Receptor Alleviating Glucose Intolerance in Turbot (Scophthalmus maximus) by Gaochan Qin, Mingzhu Pan, Dong Huang, Xinxin Li, Yue Liu, Xiaojun Yu, Kangsen Mai, Wenbing Zhang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11640315.txt.
Description
Gaochan Qin and co-authors studied how a hormone sensing protein controls sugar handling in the liver of turbot, a carnivorous fish, in work published in 2024. In mammals this protein is a key switch for glucose control, but its role in fish was unclear. The team worked with fish liver cells and cloned the full gene.
The protein was most active in the liver, and high sugar lowered its levels. When switched on, it raised genes that burn sugar and lowered genes that make new sugar, in part by binding their control regions directly. A partner protein carried part of the effect. Enzyme tests backed the gene results. The authors propose the switch as a target to improve sugar tolerance in farmed fish.
Catalog record
| CREATOR | Gaochan Qin, Mingzhu Pan, Dong Huang, Xinxin Li, Yue Liu, Xiaojun Yu, Kangsen Mai, Wenbing Zhang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |