Herpes Simplex Virus 1 Infection of Human Brain Organoids and Pancreatic Stem Cell-Islets Drives Organoid-Specific Transcripts Associated with Alzheimer’s Disease and Autoimmune Diseases
Jonathan Sundstrom, Emma Vanderleeden, Nathaniel J Barton, Sambra D Redick, Pepper Dawes, Liam F Murray, Meagan N Olson, Khanh Tran, Samantha M Chigas, Adrian R Orszulak, George M Church, Benjamin Readhead, Hyung Suk Oh, David M Harlan, David M Knipe, Jennifer P Wang, Yingleong Chan, Elaine T Lim, G · 2024
Read Herpes Simplex Virus 1 Infection of Human Brain Organoids and Pancreatic Stem Cell-Islets Drives Organoid-Specific Transcripts Associated with Alzheimer’s Disease and Autoimmune Diseases by Jonathan Sundstrom, Emma Vanderleeden, Nathaniel J Barton, Sambra D Redick, Pepper Dawes, Liam F Murray, Meagan N Olson, Khanh Tran, Samantha M Chigas, Adrian R Orszulak, George M Church, Benjamin Readhead, Hyung Suk Oh, David M Harlan, David M Knipe, Jennifer P Wang, Yingleong Chan, Elaine T Lim, G (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11640215.txt.
Description
Jonathan Sundstrom and a very large team of co-authors published this 2024 study infecting lab-grown human tissues with herpes simplex virus 1 to watch which disease genes wake up. The virus has been linked to Alzheimer's disease, and viral inflammation is suspected in type 1 diabetes too. The team exposed dissociated brain organoid cells and stem-cell pancreatic islets, then read their transcripts.
The two tissues answered differently. Infected islets lit up genes tied to autoimmune diseases, type 1 diabetes loudest, with rheumatoid arthritis, psoriasis, Crohn's, and multiple sclerosis behind. Infected brain cells lit up only Alzheimer's-linked genes. The antiviral acyclovir rescued the brain pattern better than the islet one. The authors frame the split as a clue to how one virus feeds different diseases in different organs.
Catalog record
| CREATOR | Jonathan Sundstrom, Emma Vanderleeden, Nathaniel J Barton, Sambra D Redick, Pepper Dawes, Liam F Murray, Meagan N Olson, Khanh Tran, Samantha M Chigas, Adrian R Orszulak, George M Church, Benjamin Readhead, Hyung Suk Oh, David M Harlan, David M Knipe, Jennifer P Wang, Yingleong Chan, Elaine T Lim, G |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |