Lack of Prophylactic Cranial Irradiation for Extensive Small-Cell Lung Cancer in Real Life, with the Emergence of Immunotherapy
Alice Daumas, Celestin Bigarre, Mohamed Boucekine, Audrey Zaccariotto, Bertrand Kaeppelin, Alice Mogenet, Etienne Gouton, Johan Pluvy, Pascale Tomasini, Xavier Muracciole, Sebastien Benzekry, Laurent Greillier, Laetitia Padovani, Akiteru Goto · 2024
Read Lack of Prophylactic Cranial Irradiation for Extensive Small-Cell Lung Cancer in Real Life, with the Emergence of Immunotherapy by Alice Daumas, Celestin Bigarre, Mohamed Boucekine, Audrey Zaccariotto, Bertrand Kaeppelin, Alice Mogenet, Etienne Gouton, Johan Pluvy, Pascale Tomasini, Xavier Muracciole, Sebastien Benzekry, Laurent Greillier, Laetitia Padovani, Akiteru Goto (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11640210.txt.
Description
Radiation to the brain can prevent lung cancer spread there, but it also clouds thinking, and its value is being rethought in the immunotherapy era. Alice Daumas and co-authors reviewed real-world care in 2024 for extensive-stage small-cell lung cancer at a French center. Fifty-six patients who qualified for preventive brain radiation were split between those who got it and those who did not.
Survival and time free of brain spread did not differ significantly between the groups. Patients without radiation lived longer on median, but they also received immunotherapy more often, which muddies the comparison. Starting fitness and a blood ratio predicted outcomes better than the radiation choice. The authors say the study found no benefit for the preventive treatment in this real-life mix.
Catalog record
| CREATOR | Alice Daumas, Celestin Bigarre, Mohamed Boucekine, Audrey Zaccariotto, Bertrand Kaeppelin, Alice Mogenet, Etienne Gouton, Johan Pluvy, Pascale Tomasini, Xavier Muracciole, Sebastien Benzekry, Laurent Greillier, Laetitia Padovani, Akiteru Goto |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |