FoxO1 Mediated by H3K27me3 Inhibits Porcine Follicular Development by Regulating the Transcription of CYP1A1
Zhi Zhou, Yuanyuan Lv, Liying Li, Xiaolong Yuan, Xiaofeng Zhou, Jiaqi Li, Jim McFarlane · 2024
Read FoxO1 Mediated by H3K27me3 Inhibits Porcine Follicular Development by Regulating the Transcription of CYP1A1 by Zhi Zhou, Yuanyuan Lv, Liying Li, Xiaolong Yuan, Xiaofeng Zhou, Jiaqi Li, Jim McFarlane (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11640192.txt.
Description
Zhi Zhou and co-authors study a gene switch in pig ovaries in a 2024 paper. The switch, FoxO1, acts in the small sacs where eggs grow. A chemical mark on gene packaging, H3K27me3, can turn the switch down.
FoxO1 was higher in young ovaries and small sacs than in mature ones. It slowed cell growth, cut one hormone, raised another, and sped cell death in the sac cells. FoxO1 also raised a second gene, CYP1A1, which slowed growth and sped an iron-linked cell death. The chain from mark to switch to gene may guide work on sow breeding and egg growth.
Catalog record
| CREATOR | Zhi Zhou, Yuanyuan Lv, Liying Li, Xiaolong Yuan, Xiaofeng Zhou, Jiaqi Li, Jim McFarlane |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |