The Vascular Endothelial Growth Factor-A121/Vascular Endothelial Growth Factor-A165 Ratio as a Predictor of the Therapeutic Response to Immune Checkpoint Inhibitors in Gastric Cancer
Yuki Hamada, Kiyonori Tanoue, Takaaki Arigami, Munekazu Yamakuchi, Masashi Okawa, Daisuke Matsushita, Kazunori Takenouchi, Shingo Yamada, Drew N Maywar, Chieri Nakayama, Yoko Oyama, Sadayuki Higashi, Chieko Fujisaki, Yuto Hozaka, Yoshiaki Kita, Teruto Hashiguchi, Takao Ohtsuka, Daniel A Vallera · 2024
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Description
A research team looked for a blood marker that predicts whether immune therapy will help stomach cancer patients, in this 2024 study. The therapy, which frees the immune system to attack tumors, works for only some patients. A growth factor called VEGF shapes immunity inside tumors, and it comes in several forms.
The team measured two forms of the factor in stored blood from thirty patients treated with one such drug. Total levels of the factor did not track with outcomes. The ratio between the two forms did: patients with a low ratio went notably longer before their cancer grew, and far more of them saw their disease controlled. The authors propose the ratio as an easy blood test for likely benefit, to be checked in larger groups.
Catalog record
| CREATOR | Yuki Hamada, Kiyonori Tanoue, Takaaki Arigami, Munekazu Yamakuchi, Masashi Okawa, Daisuke Matsushita, Kazunori Takenouchi, Shingo Yamada, Drew N Maywar, Chieri Nakayama, Yoko Oyama, Sadayuki Higashi, Chieko Fujisaki, Yuto Hozaka, Yoshiaki Kita, Teruto Hashiguchi, Takao Ohtsuka, Daniel A Vallera |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |