JRM-28, a Novel HDAC2 Inhibitor, Upregulates Plasticity-Associated Proteins in Hippocampal Neurons and Enhances Morphological Plasticity via Activation of CREB: Implications for Alzheimer’s Disease
A F M Towheedur Rahman, Sarojini Bulbule, Jawad Bin Belayet, Anna Benko, Carl Gunnar Gottschalk, David N Frick, Leggy A Arnold, M Mahmun Hossain, Avik Roy, Katsuhiko Tabuchi · 2024
Read JRM-28, a Novel HDAC2 Inhibitor, Upregulates Plasticity-Associated Proteins in Hippocampal Neurons and Enhances Morphological Plasticity via Activation of CREB: Implications for Alzheimer’s Disease by A F M Towheedur Rahman, Sarojini Bulbule, Jawad Bin Belayet, Anna Benko, Carl Gunnar Gottschalk, David N Frick, Leggy A Arnold, M Mahmun Hossain, Avik Roy, Katsuhiko Tabuchi (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11640089.txt.
Description
A research team reports tests of a new compound called JRM-28 in a 2024 brain study. JRM-28 blocks HDAC2, an enzyme that can turn down genes tied to learning and memory. The team studied nerve cells from the hippocampus, a brain area that helps form memories. Their interest comes from Alzheimer's disease, where memory and thinking fade over time.
In cell tests, the compound raised spine density and strengthened signals between nerve cells. It also switched on CREB, a protein that turns on genes tied to flexible, lasting connections. The same effects showed up in human nerve cells grown from stem cells of Alzheimer's patients. The authors present the compound as a lead worth more study, not a proven treatment.
Catalog record
| CREATOR | A F M Towheedur Rahman, Sarojini Bulbule, Jawad Bin Belayet, Anna Benko, Carl Gunnar Gottschalk, David N Frick, Leggy A Arnold, M Mahmun Hossain, Avik Roy, Katsuhiko Tabuchi |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |