HIV-1 Tat Protein and Cigarette Smoke Mediated ADAM17 Upregulation Can Lead to Impaired Mucociliary Clearance
Kingshuk Panda, Maria J Santiago, Md Sohanur Rahman, Suvankar Ghorai, Stephen M Black, Irfan Rahman, Hoshang J Unwalla, Srinivasan Chinnapaiyan, Philippe Gallay · 2024
Read HIV-1 Tat Protein and Cigarette Smoke Mediated ADAM17 Upregulation Can Lead to Impaired Mucociliary Clearance by Kingshuk Panda, Maria J Santiago, Md Sohanur Rahman, Suvankar Ghorai, Stephen M Black, Irfan Rahman, Hoshang J Unwalla, Srinivasan Chinnapaiyan, Philippe Gallay (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11640087.txt.
Description
Kingshuk Panda and co-authors trace how HIV and cigarette smoke damage airway cleaning in this 2024 paper. People living with HIV suffer heavy lung disease. Healthy airways sweep mucus upward with beating cilia. In smokers and HIV patients that sweep fails: cilia shorten, beat weakly, and mucus overflows. The team found a chain of molecular events in airway cells. An HIV protein raises a small RNA, which suppresses a protective gene. That lifts a protease, ADAM17, that switches on Notch signaling.
Smoke pushes the same protease up. With the protective gene down and the protease high, cells grow fewer cilia and pour out mucus. The end state matches the chronic bronchitis picture. The authors present the chain as a set of drug targets: block the small RNA, restore the protector, or rein in the protease. For this population, mechanism level maps guide the search for relief.
Catalog record
| CREATOR | Kingshuk Panda, Maria J Santiago, Md Sohanur Rahman, Suvankar Ghorai, Stephen M Black, Irfan Rahman, Hoshang J Unwalla, Srinivasan Chinnapaiyan, Philippe Gallay |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |