The Mechanism of Relieving Diarrheal Irritable Bowel Syndrome Using Polyphenols from Ribes nigrum L. Based on a Network Pharmacology Analysis and 16S rRNA Sequencing
Xi Yu, Xiaotian Wang, Xintong Liu, Fangfei Li, Yihong Bao, Yangyang Chai, Jong-Sang Kim · 2024
Read The Mechanism of Relieving Diarrheal Irritable Bowel Syndrome Using Polyphenols from Ribes nigrum L. Based on a Network Pharmacology Analysis and 16S rRNA Sequencing by Xi Yu, Xiaotian Wang, Xintong Liu, Fangfei Li, Yihong Bao, Yangyang Chai, Jong-Sang Kim (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11640074.txt.
Description
Xi Yu and six co-authors test blackcurrant polyphenols against diarrheal irritable bowel syndrome in mice, in work from 2024. The condition brings diarrhea, stomach pain and bloating. Network pharmacology first mapped likely targets of the plant compounds, then mice with the condition were treated and checked on stool water, transit time, immune scores and tissue state.
Treated mice had drier stools, better immune scores and lower levels of inflammatory substances. Gut sequencing showed more Bacteroides, Alloprevotella and Alistipes after treatment, a shift in the gut community. Gene checks tied the benefit to blocking the FoxO pathway. The authors present the fruit compounds as a candidate aid worth further study.
Catalog record
| CREATOR | Xi Yu, Xiaotian Wang, Xintong Liu, Fangfei Li, Yihong Bao, Yangyang Chai, Jong-Sang Kim |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |