Wnt Signaling in Hepatocellular Carcinoma: Biological Mechanisms and Therapeutic Opportunities
Yingying Zhu, Yajing He, Runliang Gan · 2024
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Description
Yingying Zhu, Yajing He, and Runliang Gan review a signalling pathway in liver cancer in a 2024 paper. The cancer, hepatocellular carcinoma, is a major cause of death worldwide. The Wnt pathway, a chain of signals that guides cell growth, is often altered in this cancer and shapes how tumours behave.
The review explains how the pathway's parts change in liver tumours and what those changes do. Effects covered include cell growth, spread, the tumour's local environment, stem-like traits, and cell recycling. Drugs that target the pathway are surveyed as a hopeful treatment route. Still, the authors note that exactly how the pathway interacts with this cancer is not fully clear, and they frame the review as groundwork for drug design.
Catalog record
| CREATOR | Yingying Zhu, Yajing He, Runliang Gan |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |