Plakin Expression in Serous Epithelial Ovarian Cancer Has the Potential to Impede Metastatic Spread and Epithelial–Mesenchymal Transition: A Comparative Expression Analysis of Immunohistochemical and In Silico Datasets
Tamsin Wesley, Ruth M. Escalona, George Kannourakis, Nuzhat Ahmed · 2024
Read Plakin Expression in Serous Epithelial Ovarian Cancer Has the Potential to Impede Metastatic Spread and Epithelial–Mesenchymal Transition: A Comparative Expression Analysis of Immunohistochemical and In Silico Datasets by Tamsin Wesley, Ruth M. Escalona, George Kannourakis, Nuzhat Ahmed (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11639978.txt.
Description
Wesley, Escalona, Kannourakis, and Ahmed study plakin proteins in ovarian cancer in twenty twenty-four. Epithelial ovarian cancer is aggressive and causes many deaths in women. Plakins are proteins that hold the cell skeleton together and support key cell processes. The team asked how plakin levels change as tumors progress.
They stained tissue from forty-eight patients for plakins and for markers of a change called EMT. That change helps cancer cells spread. Two plakins, periplakin and plectin, were lower in high grade than in low grade tumors. High levels of them tracked with an epithelial, less mobile cell state. Public data sets and cell lines supported the tissue findings. The authors suggest partial loss of plakins may free signaling that starts EMT.
Catalog record
| CREATOR | Tamsin Wesley, Ruth M. Escalona, George Kannourakis, Nuzhat Ahmed |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |