The Downregulation of CRIF1 Exerts Antitumor Effects Partially via TP53-Induced Glycolysis and Apoptosis Regulator Induction in BT549 Breast Cancer Cells
Shuyu Piao, Seonhee Kim, Giang-Huong Vu, Minsoo Kim, Eun-Ok Lee, Byeong Hwa Jeon, Cuk-Seong Kim · 2024
Read The Downregulation of CRIF1 Exerts Antitumor Effects Partially via TP53-Induced Glycolysis and Apoptosis Regulator Induction in BT549 Breast Cancer Cells by Shuyu Piao, Seonhee Kim, Giang-Huong Vu, Minsoo Kim, Eun-Ok Lee, Byeong Hwa Jeon, Cuk-Seong Kim (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11639960.txt.
Description
Shuyu Piao and co-authors test whether silencing a mitochondrial protein can fight triple-negative breast cancer, a subtype with few targeted drug options. The protein, CRIF1, keeps the cell's energy plants running, and tumors lean on that power. In three cell lines, lowering CRIF1 slowed growth, most sharply in BT549 cells, and curbed their spread in scratch and chamber tests.
The cells' energy output fell, their membranes lost charge, and a stress-and-death regulator rose, halting the cell cycle. Restoring a partner protein undid the benefit, confirming the pathway. The authors propose CRIF1 blockade as a treatment angle for this hard cancer.
Catalog record
| CREATOR | Shuyu Piao, Seonhee Kim, Giang-Huong Vu, Minsoo Kim, Eun-Ok Lee, Byeong Hwa Jeon, Cuk-Seong Kim |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |