Identification of Candidate Hub Genes and Drug Targets for Cholangiocarcinoma via Juhua (Chrysanthemum Morifolium) Bioactivity and Molecular Docking: A Bioinformatics Approach
Song Yang, Wan-Liang Sun, Shuo Zhou, Zheng Lu · 2024
Read Identification of Candidate Hub Genes and Drug Targets for Cholangiocarcinoma via Juhua (Chrysanthemum Morifolium) Bioactivity and Molecular Docking: A Bioinformatics Approach by Song Yang, Wan-Liang Sun, Shuo Zhou, Zheng Lu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11639890.txt.
Description
Song Yang and co-authors search in 2024 for hub genes and drug targets in bile duct cancer using data from a chrysanthemum-based herbal formula. The cancer has poor outcomes and few treatment options. They combined gene expression, co-expression networks, and genetic causal analysis to find molecular drivers instead of relying on single data sources alone for the search.
Enrichment analysis pointed to cancer-related processes in tumor samples. Intersecting network modules with the herb's known targets gave four candidate hub genes. Docking tests showed the herb's compounds bind those genes. Genetic analysis also implicated fourteen immune-related genes as causal factors in disease risk.
Catalog record
| CREATOR | Song Yang, Wan-Liang Sun, Shuo Zhou, Zheng Lu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |