Unveiling Smyd-2’s Role in Cytoplasmic Nrf-2 Sequestration and Ferroptosis Induction in Hippocampal Neurons After Cerebral Ischemia/Reperfusion
Daohang Liu, Yizhun Zhu, Alessia Remigante, Rossana Morabito · 2024
Read Unveiling Smyd-2’s Role in Cytoplasmic Nrf-2 Sequestration and Ferroptosis Induction in Hippocampal Neurons After Cerebral Ischemia/Reperfusion by Daohang Liu, Yizhun Zhu, Alessia Remigante, Rossana Morabito (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11639856.txt.
Description
Daohang Liu and co-authors study a protein that may drive a type of cell death in the brain after a stroke, in a paper from 2024. The protein, called Smyd-2, tags other proteins with a small chemical mark. The cell death in question, called ferroptosis, is driven by fat damage in cell walls.
Working with brain cells and mouse models of blocked and restored blood flow, the team found that removing the protein guarded cells from this death. It did not guard against two other forms of cell death. The guard effect ran through a known defense path that helps cells fight damage. In mice, loss of the protein cut fat damage in a key memory area of the brain. The work names a possible drug target.
Catalog record
| CREATOR | Daohang Liu, Yizhun Zhu, Alessia Remigante, Rossana Morabito |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |