Exploring Genomic Biomarkers for Pembrolizumab Response: A Real-World Approach and Patient Similarity Network Analysis Reveal DNA Response and Repair Gene Mutations as a Signature
Marco Filetti, Mario Occhipinti, Alessio Cirillo, Fabio Scirocchi, Alessio Ugolini, Raffaele Giusti, Pasquale Lombardi, Gennaro Daniele, Andrea Botticelli, Giuseppe Lo Russo, Filippo De Braud, Paolo Marchetti, Marianna Nuti, Elisabetta Ferretti, Lorenzo Farina, Aurelia Rughetti, Manuela Petti, Barba · 2024
Read Exploring Genomic Biomarkers for Pembrolizumab Response: A Real-World Approach and Patient Similarity Network Analysis Reveal DNA Response and Repair Gene Mutations as a Signature by Marco Filetti, Mario Occhipinti, Alessio Cirillo, Fabio Scirocchi, Alessio Ugolini, Raffaele Giusti, Pasquale Lombardi, Gennaro Daniele, Andrea Botticelli, Giuseppe Lo Russo, Filippo De Braud, Paolo Marchetti, Marianna Nuti, Elisabetta Ferretti, Lorenzo Farina, Aurelia Rughetti, Manuela Petti, Barba (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11639826.txt.
Description
Filetti leads a large team hunting genomic markers of response to pembrolizumab, in work from twenty twenty-four. Pembrolizumab is an immunotherapy used across many cancers, but only some patients respond. Real world marker data can complement trial findings.
The team used a patient similarity network approach on real world cases. Mutations in DNA response and repair genes emerged as a signature of response. Damaged repair systems may make tumors more visible to the immune system once its brakes are released. A repair based signature could help select patients for a costly therapy with more confidence.
Catalog record
| CREATOR | Marco Filetti, Mario Occhipinti, Alessio Cirillo, Fabio Scirocchi, Alessio Ugolini, Raffaele Giusti, Pasquale Lombardi, Gennaro Daniele, Andrea Botticelli, Giuseppe Lo Russo, Filippo De Braud, Paolo Marchetti, Marianna Nuti, Elisabetta Ferretti, Lorenzo Farina, Aurelia Rughetti, Manuela Petti, Barba |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |