The Emerging Role of Long Noncoding RNAs in Sorafenib Resistance Within Hepatocellular Carcinoma
Puneet Vij, Mohammad Shabir Hussain, Sanjaya K. Satapathy, Everardo Cobos, Manish K. Tripathi · 2024
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Description
Puneet Vij, Mohammad Shabir Hussain, Sanjaya K. Satapathy, Everardo Cobos, and Manish K. Tripathi review how long noncoding RNAs drive drug resistance in liver cancer, in a review paper from 2024. Sorafenib is a standard drug for advanced liver cancer, yet most patients stop responding over time. These long RNA strands help tumors grow and resist drugs.
The review gathers what is known about how the strands feed resistance. Roles include drug transport, receptor paths, and control of cell death. Other forces, such as tumor surroundings, also play a part. The authors map the gaps in current knowledge and point to these RNAs as possible targets for restoring drug response.
Catalog record
| CREATOR | Puneet Vij, Mohammad Shabir Hussain, Sanjaya K. Satapathy, Everardo Cobos, Manish K. Tripathi |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |