SIRT2 Inhibition by AGK2 Promotes Perinuclear Cytoskeletal Organisation and Reduces Invasiveness of MDA-MB-231 Triple-Negative Breast Cancer Cells in Confined In Vitro Models
Emily Jessop, Natalie Young, Beatriz Garcia-Del-Valle, Jack T. Crusher, Boguslaw Obara, Iakowos Karakesisoglou · 2024
Read SIRT2 Inhibition by AGK2 Promotes Perinuclear Cytoskeletal Organisation and Reduces Invasiveness of MDA-MB-231 Triple-Negative Breast Cancer Cells in Confined In Vitro Models by Emily Jessop, Natalie Young, Beatriz Garcia-Del-Valle, Jack T. Crusher, Boguslaw Obara, Iakowos Karakesisoglou (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11639776.txt.
Description
Emily Jessop and co-authors test whether blocking an enzyme can make an aggressive breast cancer cell less able to invade. Their 2024 paper studies triple-negative breast cancer, a subtype with no hormone targets and high spread rates. Soft nuclei help these cells squeeze through tight spaces, so stiffening the nucleus could slow them.
The team blocked the enzyme SIRT2 with a specific drug in a standard cell line. Treated cells built a more organized cage of fibers around the nucleus. Their nuclei resisted collapse under osmotic shock better than untreated cells. In scratch tests, the treated cells showed polarity faults that hamper directed movement. Confined models showed reduced invasiveness. The work is cell-level, but it names a mechanical route against metastasis worth testing further.
Catalog record
| CREATOR | Emily Jessop, Natalie Young, Beatriz Garcia-Del-Valle, Jack T. Crusher, Boguslaw Obara, Iakowos Karakesisoglou |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |