Primary cartilage transcriptional signatures reflect cell-type-specific molecular pathways underpinning osteoarthritis
Georgia Katsoula, John E.G. Lawrence, Ana Luiza Arruda, Mauro Tutino, Petra Balogh, Lorraine Southam, Diane Swift, Sam Behjati, Sarah A. Teichmann, J. Mark Wilkinson, Eleftheria Zeggini · 2024
Read Primary cartilage transcriptional signatures reflect cell-type-specific molecular pathways underpinning osteoarthritis by Georgia Katsoula, John E.G. Lawrence, Ana Luiza Arruda, Mauro Tutino, Petra Balogh, Lorraine Southam, Diane Swift, Sam Behjati, Sarah A. Teichmann, J. Mark Wilkinson, Eleftheria Zeggini (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11639091.txt.
Description
Georgia Katsoula and a large team read the gene marks of joint cartilage in the wear disease of joints, to bare the paths that drive it. Their study is from two thousand twenty-four.
Work to turn such reads into cures is held back by a dim grasp of the disease at the small-scale level. The team found strong shifts in gene use between high- and low-grade worn tissue. Those shifts point to growth-stage paths, of the kind seen in the limb as it forms in the womb. Low-grade tissue lifts the marks of one cell kind; high-grade tissue, of bone-forming cells. Gene risk marks for the disease bunch in a set of joint gene groups.
Catalog record
| CREATOR | Georgia Katsoula, John E.G. Lawrence, Ana Luiza Arruda, Mauro Tutino, Petra Balogh, Lorraine Southam, Diane Swift, Sam Behjati, Sarah A. Teichmann, J. Mark Wilkinson, Eleftheria Zeggini |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 80 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |