Enantioselective Synthesis of vic-Aminoalcohol Derivatives by Nickel-Catalyzed Reductive Coupling of Aldehydes with Protected Amino-pentadienoates
Thilo Bender, Alois Fürstner · 2024
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Description
Thilo Bender and Alois Fürstner report a nickel-catalyzed route to a useful class of chiral building blocks in a 2024 paper. The products join an amino group and an alcohol group on neighboring carbons, a pattern common in drugs and natural products. Their method couples aldehydes with protected amino diene esters under reducing conditions.
A special ligand, derived from a known chiral scaffold, flips the usual regiochemistry of the coupling. The products form in good yields with high optical purity and the opposite configuration to the usual pattern. A bench-stable nickel source and a boron promoter make the setup practical.
Catalog record
| CREATOR | Thilo Bender, Alois Fürstner |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 15 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |