Efficient Production of 3′-Sialyllactose Using Escherichia coli
Xinyang Lv, Xiangsong Chen, Yifan Liu, Lixia Yuan, Jinyong Wu, Jianming Yao · 2024
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Description
Xinyang Lv and colleagues published a 2024 biotechnology study on making a human milk sugar. The sugar supports infant immune health. Formula makers increasingly add it to products. The team engineered E. coli bacteria to produce it. Earlier routes were too inefficient.
Genes that break down a key building block were deleted. New genes for building the sugar were inserted. Enzyme levels were balanced in modules. A helper chemical supply was recycled more efficiently. Transport proteins were screened to export the product. Output rose substantially. Fermentation could supply this ingredient at industrial scale.
Catalog record
| CREATOR | Xinyang Lv, Xiangsong Chen, Yifan Liu, Lixia Yuan, Jinyong Wu, Jianming Yao |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |