The Role of Glycocalyx Diversity and Thickness for Nanoparticle Internalization in M1-/M2-like Macrophages
Yu Liu, Yubei He, Han Xu, Amani Remmo, Frank Wiekhorst, Felix Heymann, Hanyang Liu, Eyk Schellenberger, Akvile Häckel, Ralf Hauptmann, Matthias Taupitz, Yu Shen, Emine Yaren Yilmaz, Dominik N Müller, Luisa Heidemann, Robin Schmidt, Lynn Jeanette Savic · 2024
Read The Role of Glycocalyx Diversity and Thickness for Nanoparticle Internalization in M1-/M2-like Macrophages by Yu Liu, Yubei He, Han Xu, Amani Remmo, Frank Wiekhorst, Felix Heymann, Hanyang Liu, Eyk Schellenberger, Akvile Häckel, Ralf Hauptmann, Matthias Taupitz, Yu Shen, Emine Yaren Yilmaz, Dominik N Müller, Luisa Heidemann, Robin Schmidt, Lynn Jeanette Savic (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11638944.txt.
Description
A large research team studies how a cell surface coat governs nanoparticle uptake in this 2024 paper. Tiny iron oxide particles are promising MRI contrast agents, and macrophages swallow most of them, but why the two macrophage types differ in appetite was unclear.
The team compared pro-inflammatory M1 cells with anti-inflammatory M2 cells. The M2 cells built sugar chains faster, wore a thicker surface coat, called the glycocalyx, and took up more particles of two kinds. Enzymes that stripped the coat cut uptake sharply. The positive link between coat thickness and uptake could be exploited for imaging and for therapies aimed at one macrophage type.
Catalog record
| CREATOR | Yu Liu, Yubei He, Han Xu, Amani Remmo, Frank Wiekhorst, Felix Heymann, Hanyang Liu, Eyk Schellenberger, Akvile Häckel, Ralf Hauptmann, Matthias Taupitz, Yu Shen, Emine Yaren Yilmaz, Dominik N Müller, Luisa Heidemann, Robin Schmidt, Lynn Jeanette Savic |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |