Restoring Compromised Cl− in D2 Neurons of a Huntington’s Disease Mouse Model Rescues Motor Disability
Melissa Serranilla, Jessica C. Pressey, Melanie A. Woodin · 2024
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Description
Melissa Serranilla and co-authors study a chloride fault in brain cells of mice with Huntington's disease, in a 2024 paper. The disease slowly kills a class of striatal nerve cells, with one subtype lost early. A protein that keeps chloride in balance inside those cells had not been checked by subtype.
The team recorded signals in both subtypes in a mouse model. The early lost subtype showed weak chloride control, and a relay station also misfired, turning a calming signal into an exciting one. Boosting the balance protein in the weak subtype delayed motor problems. The work names chloride control as a target for early care.
Catalog record
| CREATOR | Melissa Serranilla, Jessica C. Pressey, Melanie A. Woodin |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |