Development of immunocompetent full thickness skin tissue constructs to model skin fibrosis for high-throughput drug screening
Yi Wei Lim, Russell Quinn, Kapil Bharti, Marc Ferrer, Hoda Zarkoob, Min Jae Song · 2025
Read Development of immunocompetent full thickness skin tissue constructs to model skin fibrosis for high-throughput drug screening by Yi Wei Lim, Russell Quinn, Kapil Bharti, Marc Ferrer, Hoda Zarkoob, Min Jae Song (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11638742.txt.
Description
Yi Wei Lim and co-authors build lab skin with a working immune part to model scarring in work dated two thousand twenty-four. The hosted text dates the work to two thousand twenty-four. Most lab skin lacks immune cells, so the interplay that drives skin disease stays hidden.
Their full-thickness skin carries macrophages, immune cells grown from blood cells, in two set moods, attack and repair. The tissue answered a bacterial trigger with proper signals and mood shifts. Adding a growth factor to the repair-mood version brought on fibrosis signs: heavy collagen buildup and scar-type cells. The format suits high-throughput screening, so drug hunters can test many compounds against scarring in skin that fights back.
Catalog record
| CREATOR | Yi Wei Lim, Russell Quinn, Kapil Bharti, Marc Ferrer, Hoda Zarkoob, Min Jae Song |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |