Target-site cefiderocol pharmacokinetics in soft tissues of healthy volunteers
Maria Sanz-Codina, Wisse van Os, Anh Duc Pham, Anselm Jorda, Michael Wölf-Duchek, Felix Bergmann, Edith Lackner, Constantin Lier, J G Coen van Hasselt, Iris K Minichmayr, Christoph Dorn, Markus Zeitlinger, Valentin al Jalali · 2024
Read Target-site cefiderocol pharmacokinetics in soft tissues of healthy volunteers by Maria Sanz-Codina, Wisse van Os, Anh Duc Pham, Anselm Jorda, Michael Wölf-Duchek, Felix Bergmann, Edith Lackner, Constantin Lier, J G Coen van Hasselt, Iris K Minichmayr, Christoph Dorn, Markus Zeitlinger, Valentin al Jalali (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11638555.txt.
Description
Maria Sanz-Codina and twelve co-authors measured how well a last-resort antibiotic reaches the soft tissues where infections live, in this 2024 study. Cefiderocol is reserved for stubborn bacteria, and it might treat skin and soft tissue infections, but only if enough of it leaves the blood and enters muscle and fat. Blood levels alone cannot promise that.
Eight healthy men received a single two-gram intravenous dose. Over eight hours the team sampled blood plasma and, using hair-thin dialysis probes, the fluid inside muscle and under-skin tissue. The drug crossed into both tissues almost completely, with average penetration near a hundred percent for the under-skin layer and ninety-two percent for muscle. Computer simulations then estimated how reliably standard dosing would hit the levels needed against target bacteria. The results support testing the drug against soft tissue infections in patients.
Catalog record
| CREATOR | Maria Sanz-Codina, Wisse van Os, Anh Duc Pham, Anselm Jorda, Michael Wölf-Duchek, Felix Bergmann, Edith Lackner, Constantin Lier, J G Coen van Hasselt, Iris K Minichmayr, Christoph Dorn, Markus Zeitlinger, Valentin al Jalali |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |