Pentraxin-3 modulates hepatocyte ferroptosis and the innate immune response in LPS-induced liver injury
Huitong Wang, Zhaojie Su, Yunyun Qian, Baojie Shi, Hao Li, Wenbin An, Yi Xiao, Cheng Qiu, Zhixiang Guo, Jianfa Zhong, Xia Wu, Jiajia Chen, Ying Wang, Wei Zeng, Linghui Zhan, Jie Wang · 2024
Read Pentraxin-3 modulates hepatocyte ferroptosis and the innate immune response in LPS-induced liver injury by Huitong Wang, Zhaojie Su, Yunyun Qian, Baojie Shi, Hao Li, Wenbin An, Yi Xiao, Cheng Qiu, Zhixiang Guo, Jianfa Zhong, Xia Wu, Jiajia Chen, Ying Wang, Wei Zeng, Linghui Zhan, Jie Wang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11638432.txt.
Description
Huitong Wang and a large team study a swelling factor that worsens liver harm in blood infection in mice. The liver is a top target when germ toxins flood the blood. Mice that lack the factor fared far better, with lower liver marks and higher survival.
Loss of the factor raised an iron import mark in liver cells and a call signal for immune cells. More immune cells came and ate debris, with a pro fight form turned up. Iron linked cell death shifts also played a role. Blocking the factor may aid care for severe infection.
Catalog record
| CREATOR | Huitong Wang, Zhaojie Su, Yunyun Qian, Baojie Shi, Hao Li, Wenbin An, Yi Xiao, Cheng Qiu, Zhixiang Guo, Jianfa Zhong, Xia Wu, Jiajia Chen, Ying Wang, Wei Zeng, Linghui Zhan, Jie Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |