Intracellular biliverdin dynamics during ferroptosis
Kazuma Nakajima, Hironari Nishizawa, Guan Chen, Shunichi Tsuge, Mie Yamanaka, Machi Kiyohara, Riko Irikura, Mitsuyo Matsumoto, Kozo Tanaka, Rei Narikawa, Kazuhiko Igarashi · 2024
Read Intracellular biliverdin dynamics during ferroptosis by Kazuma Nakajima, Hironari Nishizawa, Guan Chen, Shunichi Tsuge, Mie Yamanaka, Machi Kiyohara, Riko Irikura, Mitsuyo Matsumoto, Kozo Tanaka, Rei Narikawa, Kazuhiko Igarashi (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11638335.txt.
Description
Kazuma Nakajima and co-authors watch a pigment fade during a cell death in a 2024 study. Ferroptosis kills cells through iron driven fat damage and may help fight cancer. Few markers can flag cells dying this way or predict which cells are prone to it. The team tracked biliverdin, a natural reducing pigment, using a light based sensor borrowed from bacteria.
Biliverdin levels fell as ferroptosis ran its course. The fall was specific: other death forms did not show it. Starting levels also predicted how sensitive a cell would be to the death trigger. A cheap pigment readout could thus sort cells by risk and confirm the death type, two tasks that now need costlier assays.
Catalog record
| CREATOR | Kazuma Nakajima, Hironari Nishizawa, Guan Chen, Shunichi Tsuge, Mie Yamanaka, Machi Kiyohara, Riko Irikura, Mitsuyo Matsumoto, Kozo Tanaka, Rei Narikawa, Kazuhiko Igarashi |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |