The volume of the subthalamic nucleus in spinocerebellar ataxia type 3: potential relevance for the clinical phenotype and treatment of parkinsonian symptoms with deep brain stimulation
Martina Minnerop, Peter Pieperhoff, Saskia Elben, Christian Johannes Hartmann, Tomke Müttel, Ulrike Kahlen, Ullrich Wüllner, Thomas Klockgether, Lars Wojtecki, Svenja Caspers, Katrin Amunts, Jan Vesper, Alfons Schnitzler, Stefan Jun Groiss · 2024
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Description
Spinocerebellar ataxia type 3 is an inherited disease that wastes the cerebellum, yet its damage reaches the subthalamic nucleus, a deep-brain hub. In a research letter, Martina Minnerop and co-authors explore a puzzle. Post-mortem studies found severe neuron loss in that nucleus in nearly all patients, except one who had shown parkinsonian symptoms. They reason that losing the nucleus may mask parkinsonism, much as stimulating it treats Parkinson's disease.
To test the idea, they measured the nucleus's volume by MRI in eleven patients, against matched controls and a reference sample of 235 older adults. The series includes the patient with parkinsonian symptoms, whose bilateral deep brain stimulation of the nucleus worked well for three years. The authors hypothesize that this patient kept a larger nucleus than most patients without symptoms. If volume predicts who can respond, it could guide stimulation decisions in this rare disease.
Catalog record
| CREATOR | Martina Minnerop, Peter Pieperhoff, Saskia Elben, Christian Johannes Hartmann, Tomke Müttel, Ulrike Kahlen, Ullrich Wüllner, Thomas Klockgether, Lars Wojtecki, Svenja Caspers, Katrin Amunts, Jan Vesper, Alfons Schnitzler, Stefan Jun Groiss |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |