Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions
Sagnik Pal, Yangyang Su, Emmanuel Nwadozi, Lena Claesson-Welsh, Mark Richards · 2024
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Description
Sagnik Pal and co-authors show that a vessel protein's effect on leakiness flips by body site. Their 2024 study treats neuropilin-1, a helper that hands a growth signal to its receptor on vessel lining cells. Past work split on whether the helper raises or lowers leak, so the team tests mice that lack the helper only in lining cells.
In ear skin, loss of the helper raised leak, while in back skin and windpipe it cut leak. A key seam protein's marks moved in step with each site. Helper levels on wrap-around cells, high in ear skin, explain much of the flip. Site context, not the protein alone, sets the sign of its action.
Catalog record
| CREATOR | Sagnik Pal, Yangyang Su, Emmanuel Nwadozi, Lena Claesson-Welsh, Mark Richards |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |