Literature review of clinical analysis of hereditary neuropathy with liability to pressure palsies
Limin Chen, Hongbo Zhang, Chunnv Li, Nuo Yang, Jiangtao Wang, Jianmin Liang · 2024
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Description
Limin Chen and five co-authors review a hereditary nerve condition in which nerves fail under pressure. Their 2024 paper covers hereditary neuropathy with liability to pressure palsies, a disorder tied to the PMP22 gene. The team combined records of patients seen at their own hospital in 2022 and 2023 with sixty-eight published studies, for 124 cases in total.
Typical attacks brought passing weakness and numbness, and most patients had repeat episodes. About a third had unusual symptoms and a small share had none. The average onset came near age twenty-six, yet diagnosis lagged to about thirty-three, with one gap of forty years. Traction or pressure triggered most attacks with a known cause. Genetic tests found the classic deletion of one PMP22 copy in about three quarters of cases and other gene changes in the rest. The authors stress the long delay as the key problem to fix.
Catalog record
| CREATOR | Limin Chen, Hongbo Zhang, Chunnv Li, Nuo Yang, Jiangtao Wang, Jianmin Liang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |