Lipid raft disruption inhibits the activation of Transient Receptor Potential Vanilloid 1, but not TRP Melastatin 3 and the voltage-gated L-type calcium channels in sensory neurons
Maja Payrits, Balázs Zoltán Zsidó, Andrea Kinga Nehr-Majoros, Rita Börzsei, Zsuzsanna Helyes, Csaba Hetényi, Éva Szőke · 2024
Read Lipid raft disruption inhibits the activation of Transient Receptor Potential Vanilloid 1, but not TRP Melastatin 3 and the voltage-gated L-type calcium channels in sensory neurons by Maja Payrits, Balázs Zoltán Zsidó, Andrea Kinga Nehr-Majoros, Rita Börzsei, Zsuzsanna Helyes, Csaba Hetényi, Éva Szőke (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11638188.txt.
Description
Maja Payrits and co-authors test whether fat rafts in cell skins gate pain channels in a 2024 study. Two heat and pain channels, TRPV1 and TRPM3, sit in cholesterol rich raft zones of sense nerves. The team broke those rafts with two agents and watched channel replies in grown nerve cells and trachea nerve ends.
Breaking rafts left TRPM3 and L type calcium channel starts untouched in both setups. TRPV1 starts, by contrast, were curbed by raft loss, as the title states. Computer modeling gave a first structural read on why cholesterol near each channel counts so unevenly. The split hints at raft based pain control that spares kin channels.
Catalog record
| CREATOR | Maja Payrits, Balázs Zoltán Zsidó, Andrea Kinga Nehr-Majoros, Rita Börzsei, Zsuzsanna Helyes, Csaba Hetényi, Éva Szőke |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |