Case report: A cyclic neutropenia patient with ELANE mutation accompanied by hemophagocytic lymphohistiocytosis
Lang Yu, Yulin Li, Wenhui Li, Yishi Zhang, Wenli He, Xuemei Tang, Yunfei An, Xiaodong Zhao · 2024
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Description
Yu and seven co-authors present a case report from twenty twenty-four on a child whose white cell counts cycle, who then developed a dangerous immune overreaction. The child's gene mutation causes neutrophil counts to rise and fall in cycles. Severe mixed infections trigger the overreaction syndrome. Killer cell function tests show impaired release machinery. The pairing of this mutation with the syndrome was undocumented before. Inborn immunity errors are known to underlie some such cases.
The authors establish the new link for clinicians. The syndrome should be watched for in these patients. Infection control becomes doubly urgent in that light. The case widens the mutation's known risks.
Catalog record
| CREATOR | Lang Yu, Yulin Li, Wenhui Li, Yishi Zhang, Wenli He, Xuemei Tang, Yunfei An, Xiaodong Zhao |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |