PARP inhibitors in testicular germ cell tumors: what we know and what we are looking for
Sara Parola, Christoph Oing, Pasquale Rescigno, Salvatore Feliciano, Francesca Carlino, Luca Pompella, Antonella Lucia Marretta, Irene De Santo, Martina Viggiani, Margherita Muratore, Bianca Arianna Facchini, Jessica Orefice, Eleonora Cioli, Francesca Sparano, Domenico Mallardo, Ugo De Giorgi, Giova · 2024
Read PARP inhibitors in testicular germ cell tumors: what we know and what we are looking for by Sara Parola, Christoph Oing, Pasquale Rescigno, Salvatore Feliciano, Francesca Carlino, Luca Pompella, Antonella Lucia Marretta, Irene De Santo, Martina Viggiani, Margherita Muratore, Bianca Arianna Facchini, Jessica Orefice, Eleonora Cioli, Francesca Sparano, Domenico Mallardo, Ugo De Giorgi, Giova (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11638157.txt.
Description
Sara Parola and co-authors review what PARP inhibitors might offer men with testicular germ cell tumors that stop answering platinum drugs. These tumors are the commonest cancers of young men and usually cure well with cisplatin. About 30 percent of advanced cases relapse, though, and resistant disease leaves few options and short survival.
PARP inhibitors jam a DNA repair path, so they should hurt cells already weak in repair. Trials so far, alone or with chemotherapy, showed little benefit in unselected patients. A few responses appeared in men whose tumors carried BRCA1/2, ATM, or CHEK2 changes. The authors argue future work should select patients by such markers and dig into why resistance forms.
Catalog record
| CREATOR | Sara Parola, Christoph Oing, Pasquale Rescigno, Salvatore Feliciano, Francesca Carlino, Luca Pompella, Antonella Lucia Marretta, Irene De Santo, Martina Viggiani, Margherita Muratore, Bianca Arianna Facchini, Jessica Orefice, Eleonora Cioli, Francesca Sparano, Domenico Mallardo, Ugo De Giorgi, Giova |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |