Global lncRNA expression signature in pre-metastatic lung and their regulatory effects in pulmonary metastasis
Huifang Shi, Peng Wang, Jiaan Wang, Lei Chen, Yan Qin, Jie Lv · 2024
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Description
Huifang Shi and co-authors map the long noncoding RNA profile of lungs that are being prepared, before any tumor arrives, to receive spreading cancer, in a study from 2024. Such prepared ground, called a pre-metastatic niche, is a required step before lung spread takes hold. These RNAs, which do not code for proteins, are known to shape spread, but their role in the niche was uncharted.
RNA reading in mouse lungs found more than two hundred of these RNAs changed versus healthy lungs. The changed set clustered in pathways for growth signals, calcium, and inflammation. One RNA in lung immune cells was studied in depth. It pushed those cells toward a state that helps tumors, shaped the niche, and altered tumor cell death, growth, and movement in dishes.
Catalog record
| CREATOR | Huifang Shi, Peng Wang, Jiaan Wang, Lei Chen, Yan Qin, Jie Lv |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |