Ubiquitination-Binding Enzyme 2C is Associated with Cancer Development and Prognosis and is a Potential Therapeutic Target
Mengjie Zhao, Jielong Li, Rui Wang, Lida Mi, Yan Gu, Rongjin Chen, Yangyang Li, Woda Shi, Yajun Zhang · 2024
Read Ubiquitination-Binding Enzyme 2C is Associated with Cancer Development and Prognosis and is a Potential Therapeutic Target by Mengjie Zhao, Jielong Li, Rui Wang, Lida Mi, Yan Gu, Rongjin Chen, Yangyang Li, Woda Shi, Yajun Zhang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11637980.txt.
Description
UBE2C is a small enzyme in the cell's protein-recycling system that also helps drive the cell division cycle, and tumors of many kinds make too much of it. Mengjie Zhao and eight co-authors review its role across cancers in a 2024 paper. High levels show up in common, deadly malignancies of the lung, breast, and food pipe, among others.
The review maps how the enzyme feeds cell growth, invasion, spread, and resistance to drugs. Because of that reach, the authors argue it could serve three jobs at once: a warning marker, a forecast of outcomes, and a drug target. They call for deeper work on how it behaves inside the tumor's surroundings, to carry it from lab finding to clinical use.
Catalog record
| CREATOR | Mengjie Zhao, Jielong Li, Rui Wang, Lida Mi, Yan Gu, Rongjin Chen, Yangyang Li, Woda Shi, Yajun Zhang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |