Gestational hypercholanemia suppresses pregnancy‐associated adipose mass increase and stimulates a pro‐inflammatory environment in mice
Vanya Nikolova, Alice L. Mitchell, Elena Bellafante, Eugene Jansen, Georgia Papacleovoulou, Per‐Olof Bergh, Hanns‐Ulrich Marshall, Catherine Williamson · 2024
Read Gestational hypercholanemia suppresses pregnancy‐associated adipose mass increase and stimulates a pro‐inflammatory environment in mice by Vanya Nikolova, Alice L. Mitchell, Elena Bellafante, Eugene Jansen, Georgia Papacleovoulou, Per‐Olof Bergh, Hanns‐Ulrich Marshall, Catherine Williamson (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11637612.txt.
Description
Vanya Nikolova and co-authors study how excess bile acids in pregnancy affect fat tissue in mice in two thousand twenty-four. A liver condition of pregnancy floods the blood with bile acids and raises blood fat risk in mothers. The team fed pregnant mice chow laced with a bile acid and matched them with non-pregnant mice.
The bile diet held back the normal growth of fat stores in pregnancy and lowered fetal weight. Blood fats shifted in a worse direction, with the harmful type up and the protective type down. Fat cells also turned down genes for fat handling. Stress and inflammation markers rose, while two calming blood factors fell by large shares.
Catalog record
| CREATOR | Vanya Nikolova, Alice L. Mitchell, Elena Bellafante, Eugene Jansen, Georgia Papacleovoulou, Per‐Olof Bergh, Hanns‐Ulrich Marshall, Catherine Williamson |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |