Intracellular polarization of RNAs and proteins in the human small intestinal epithelium
Roy Novoselsky, Yotam Harnik, Oran Yakubovsky, Corine Katina, Yishai Levin, Keren Bahar Halpern, Niv Pencovich, Ido Nachmany, Shalev Itzkovitz, Ines Alvarez-Garcia, Ines Alvarez-Garcia, Ines Alvarez-Garcia, Ines Alvarez-Garcia · 2024
Read Intracellular polarization of RNAs and proteins in the human small intestinal epithelium by Roy Novoselsky, Yotam Harnik, Oran Yakubovsky, Corine Katina, Yishai Levin, Keren Bahar Halpern, Niv Pencovich, Ido Nachmany, Shalev Itzkovitz, Ines Alvarez-Garcia, Ines Alvarez-Garcia, Ines Alvarez-Garcia, Ines Alvarez-Garcia (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11637431.txt.
Description
Roy Novoselsky and eight co-authors map how molecules sort themselves inside human gut lining cells. The intestinal epithelium is a polarized sheet, with an apical side facing the gut lumen and a basal side facing the blood. Mice show global sorting of proteins and messenger RNAs along that axis, but human data were lacking. Laser-capture microdissection cut apical and basal slices from tissue of eight people for RNA sequencing and proteomics.
Human messenger RNA sorting proved substantial and largely matched the mouse pattern, steady across villus zones. Protein sorting broadly followed the RNA sorting. Nutrient handling looked streamlined, while mitochondria and ribosomes sorted less strongly in humans than in mice.
Catalog record
| CREATOR | Roy Novoselsky, Yotam Harnik, Oran Yakubovsky, Corine Katina, Yishai Levin, Keren Bahar Halpern, Niv Pencovich, Ido Nachmany, Shalev Itzkovitz, Ines Alvarez-Garcia, Ines Alvarez-Garcia, Ines Alvarez-Garcia, Ines Alvarez-Garcia |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |