Bacterial TonB-dependent transducers interact with the anti-σ factor in absence of the inducing signal protecting it from proteolysis
Sarah Wettstadt, Francisco J. Marcos-Torres, Joaquín R. Otero-Asman, Alicia García-Puente, Álvaro Ortega, María A. Llamas, Melissa Vazquez Hernandez, Melissa Vazquez Hernandez, Melissa Vazquez Hernandez, Melissa Vazquez Hernandez · 2024
Read Bacterial TonB-dependent transducers interact with the anti-σ factor in absence of the inducing signal protecting it from proteolysis by Sarah Wettstadt, Francisco J. Marcos-Torres, Joaquín R. Otero-Asman, Alicia García-Puente, Álvaro Ortega, María A. Llamas, Melissa Vazquez Hernandez, Melissa Vazquez Hernandez, Melissa Vazquez Hernandez, Melissa Vazquez Hernandez (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11637429.txt.
Description
Sarah Wettstadt and co-authors revise the standard story of how a bacterium switches on its iron-gathering machinery. Pseudomonas aeruginosa, a germ that infects humans, pulls iron from carriers through receptors in its outer membrane. Making those receptors is normally triggered by a signaling chain that runs from the receptor, through a guard protein, to a transcription factor.
Working on the Fox system of this bacterium, the team shows the chain behaves differently from the textbook model. The receptor's signaling domain already grips the guard protein when no iron signal is present. That grip shields the guard from being cut up, which keeps the response genes off. Computer modeling pinned down where the two proteins touch. To play this protective role, the receptor itself gets clipped. The authors say the finding changes the paradigm for this class of signaling systems.
Catalog record
| CREATOR | Sarah Wettstadt, Francisco J. Marcos-Torres, Joaquín R. Otero-Asman, Alicia García-Puente, Álvaro Ortega, María A. Llamas, Melissa Vazquez Hernandez, Melissa Vazquez Hernandez, Melissa Vazquez Hernandez, Melissa Vazquez Hernandez |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 93 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |