Gut microbiota diversity repeatedly diminishes over time following maintenance infliximab infusions in paediatric IBD patients
Katrine Carlsen, Louise B. Thingholm, Astrid Dempfle, Mikkel Malham, Corinna Bang, Andre Franke, Vibeke Wewer, Jonathan Jacobs, Jonathan Jacobs, Jonathan Jacobs, Jonathan Jacobs · 2024
Read Gut microbiota diversity repeatedly diminishes over time following maintenance infliximab infusions in paediatric IBD patients by Katrine Carlsen, Louise B. Thingholm, Astrid Dempfle, Mikkel Malham, Corinna Bang, Andre Franke, Vibeke Wewer, Jonathan Jacobs, Jonathan Jacobs, Jonathan Jacobs, Jonathan Jacobs (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11637414.txt.
Description
Katrine Carlsen and co-authors report a 2024 study of gut germs in children with bowel inflammation. Inflammatory bowel disease is partly driven by the gut microbiome. The team tracks children on maintenance infliximab, a infused antibody drug. Infusions run every four to twelve weeks, timed by stool marker and symptom scores. Extra stool samples underwent gene-based germ profiling. The question is whether germ diversity tracks time since infusion and disease activity.
Diversity dips repeatedly after each infusion, as the title states. A sawtooth pattern emerges across cycles rather than a steady drift. Doctors get a timing insight: samples taken at unlike cycle points are not comparable. Microbiome-guided care must respect the infusion clock. The repeated dip also hints that the drug, or the disease flare it answers, reshapes the gut on a schedule. That rhythm is a new variable for pediatric IBD research.
Catalog record
| CREATOR | Katrine Carlsen, Louise B. Thingholm, Astrid Dempfle, Mikkel Malham, Corinna Bang, Andre Franke, Vibeke Wewer, Jonathan Jacobs, Jonathan Jacobs, Jonathan Jacobs, Jonathan Jacobs |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |