Homeodynamic feedback inhibition control in whole-brain simulations
Jan Stasinski, Halgurd Taher, Jil Mona Meier, Michael Schirner, Dionysios Perdikis, Petra Ritter, Lyle J. Graham, Marcus Kaiser, Lyle J. Graham, Marcus Kaiser, Lyle J. Graham, Marcus Kaiser · 2024
Read Homeodynamic feedback inhibition control in whole-brain simulations by Jan Stasinski, Halgurd Taher, Jil Mona Meier, Michael Schirner, Dionysios Perdikis, Petra Ritter, Lyle J. Graham, Marcus Kaiser, Lyle J. Graham, Marcus Kaiser, Lyle J. Graham, Marcus Kaiser (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11637364.txt.
Description
Jan Stasinski and co-authors add a self-tuning brake to whole-brain simulations so they stop overheating, in a study published in 2024. Brain network models often blow up into implausible overexcitation because real connection strengths are heavily skewed. Their fix, dynamic feedback inhibitory control, adjusts each region's inhibitory coupling on the fly toward a target activity level. It is implemented in a standard neural mass model inside a widely used simulation platform.
The controlled simulations produced realistic signals, from local field traces to simulated fMRI patterns. The authors derive the conditions under which activity settles at the target and confirm them in runs. The method also widened the range of dynamics the model could show. Fits to real fMRI data, static and dynamic, improved. They offer the controller as an easy tuning tool for computational neuroscientists.
Catalog record
| CREATOR | Jan Stasinski, Halgurd Taher, Jil Mona Meier, Michael Schirner, Dionysios Perdikis, Petra Ritter, Lyle J. Graham, Marcus Kaiser, Lyle J. Graham, Marcus Kaiser, Lyle J. Graham, Marcus Kaiser |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 99 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |