A Six-Gene Signature Related to Liquid-Liquid Phase Separation for Diagnosis of Alzheimer's Disease
Chao Qiu, Hui Xu · 2024
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Description
Qiu and Xu published in twenty twenty-four a study building a gene test for Alzheimer's disease from a cell process called phase separation. In this process, cell contents sort into droplet-like zones. The process is linked to several brain diseases, but good diagnostic markers are scarce. The pair gathered one hundred forty-nine related genes from databases. Network and regression tools narrowed that list to six key genes.
A risk model built on those six genes sorted patients well in several data sets. Accuracy stayed high in training, internal checks, and two outside sets. The genes tie to oxidative stress, cell death, and cancer pathways. Their levels also tracked immune cell presence in tissue. The authors offer the signature as an aid to earlier detection.
Catalog record
| CREATOR | Chao Qiu, Hui Xu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |